• Annexin A ANXA a member of annexin

  2022-09-22

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

• GSTP is a class Glutathione S transferase GST enzyme

  2022-09-22

  

  GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting [D-Lys3]-GHRP-6 against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in prostate carcin

• H-Lys(Ac)-OH.HCl Nitrosylation mediated post translational

  2022-09-22

  

  Nitrosylation-mediated post-translational modifications of proteins through GSNOR play critical roles in modulating plant defense responses to diverse abiotic and biotic stresses (Frungillo et al., 2013, Leterrier 2011). As the most fundamental and intricate physiological process of plants, photosyn

• In women with stage I II endometriosis

  2022-09-22

  

  In women with stage I–II endometriosis [17], no difference in the implantation rate per embryo or in the clinical pregnancy rate per transfer was noted between GnRH-agonist and GnRH-antagonist protocol (18.2% vs. 15.4%, P=0.9 and 31.2% vs. 30%, P=1, respectively). It has been suggested that either

• Elimination of the Q R bridge significantly affected the

  2022-09-21

  

  Elimination of the Q234–R244 bridge significantly affected the protein nefiracetam receptor but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the

• Introduction l Glutamate is a major excitatory neurotransmit

  2022-09-21

  

  Introduction l-Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system (CNS) that contributes not only to fast synaptic neurotransmission, but also to complex physiological processes like memory, learning, plasticity, and neuronal cell death [30], [81]. Glutamate is

• br Conclusions The results of this work showed that

  2022-09-21

  

  Conclusions The results of this work showed that β-glucosidase could be efficiently immobilized onto hydroxyapatite nanoparticles in a single adsorption step. The enzyme adsorption was accomplished by coordination bonds between remaining Ca2+ sites of HA and COO− of amino acids. The immobilizatio

• A localization of GK to both a cytoplasmic and perinuclear

  2022-09-21

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• Xenobiotic metabolizing enzymes are classified

  2022-09-21

  

  Xenobiotic metabolizing enzymes are classified as being phase I, phase II and transporter enzymes, with phase I enzymes metabolizing lipophyllic xenobiotics to make them more polar so that the phase II enzymes can perform the necessary conjugation reactions that afford elimination. Although the phas

• In conclusion enhanced glucagon action of the

  2022-09-21

  

  In conclusion, enhanced glucagon action of the beta cell results in improved beta cell function after glucose stimulation, but simultaneously dissociated responses to both glucose-dependent and non-glucose secretagogues evolve. This shows that the glucagon receptor is complexly involved in beta cell

• Analysis of genomic neighborhoods has helped resolve

  2022-09-21

  

  Analysis of genomic neighborhoods has helped resolve questions concerning the orthology of receptors for peptides similar to glucagon (Ng et al., 2010, Irwin and Prentice, 2011, Wang et al., 2012, Hwang et al., 2013). Using a diverse array of species with available genome sequence (see Fig. 4) the g

• br Introduction Glucose homeostasis is primarily

  2022-09-21

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β EIPA is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory hormone t

• Comparison of dlGALRs deduced amino acid sequences with that

  2022-09-21

  

  Comparison of dlGALRs deduced amino ap-1 sequences with that of human GALRs demonstrate that the GALR1 ortholog sequences have diverged less than those of GALR2. Since often duplicate genes undergo divergent evolution through sub-functionalization, loss or gain of new functions (Prince and Pickett,

• In our study the changes in the and subunit

  2022-09-21

  

  In our study, the changes in the α4 and δ subunit expression were accompanied by a significant increase in γ2 subunit expression in almost all analysed hippocampal structures in the fully kindled animals. In contrast, an acute injection of PTZ at a convulsive dose (55mg/kg) evoked a potent decrease

• The results obtained here in int Gr and

  2022-09-21

  

  The results obtained here in int-Gr+/+ and int-Gr−/− mice suggested that Gr is required to maintain basal level of Fgf15 expression in the ileum, whereas DEX treatment is able to reduce Fgf15 mRNA in a Gr-independent manner. In previous in vitro studies we have already shown that GC are able to affe

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