• Ligand binding RTK activation induces the endocytic internal

  2021-01-21

  

  Ligand binding (RTK activation) induces the endocytic internalization of RTKs, and this has been demonstrated for CSF-1R [15], [16], [17]. Endocytosed RTKs are targeted to the lysosome, which we and others have established to be dependent on ubiquitination via CBL-family and recognition by ESCRT com

• Nile tilapia Oreochromis niloticus is an important species f

  2021-01-21

  

  Nile tilapia (Oreochromis niloticus) is an important species farmed worldwide (Doan et al., 2018). Lipid-rich diets are commonly used in Nile tilapia aquaculture to reduce feed cost, but impair lipid homeostasis (Huang et al., 2016). Therefore, it is important to determine whether forskolin can sti

• Furthermore positioning the naphthalene nucleus in d within

  2021-01-21

  

  Furthermore, positioning the naphthalene nucleus in 3d within the main active site and forming one hydrogen bond with Tyr385 in addition to many hydrophobic interactions with Val349, Leu352, Gly526, Ala527 and Leu531 residues, correlates well with the position and hydrophobic interactions of the tri

• Due to the results of the experiment we decided

  2021-01-21

  

  Due to the results of the experiment we decided to deploy our cloud service infrastructure with two platform-independent servers instead of one or three. This decision was based on two factors: (a) the use of more than one server is useful to avoid a bottleneck in the system, and (b) using more than

• WAY-262611 australia br Funding This work was partly support

  2021-01-21

  

  Funding This work was partly supported by the grant ‘Maria Grazia Cuccoli’ from Fondazione Cassa di Risparmio di Bologna. Declarations of interest Acknowledgements Introduction The main strategy of oncolytic viral therapy is based on the fact that naturally occurring or engineered virus

• The development of novel approaches to study GPCR mediated

  2021-01-21

  

  The development of novel approaches to study GPCR-mediated transactivation in live LY2409881 is important, and this study describes a unique BRET-based quantification of Grb2 recruitment to the EGFR as a direct readout of GPCR-mediated transactivation. We have previously used the recruitment of Grb

• br Introduction Detection of driver mutations in patients

  2021-01-21

  

  Introduction Detection of driver mutations in patients with advanced non-small cell lung cancer (NSCLC) is critical because they receive great benefit from kinase inhibitors [[1], [2], [3], [4]]. However, it is often difficult to obtain tumor tissue in advanced NSCLC patients. Cell-free DNA (cfDN

• br Conclusion br Conflicts of interest br Acknowledgements T

  2021-01-20

  

  Conclusion Conflicts of interest Acknowledgements This study was supported by Amsacrine grant (14182MFDS979) from the Korea Food and Drug Administration, by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (#NRF

• High throughput screening HTS of the AstraZeneca

  2021-01-20

  

  High throughput screening (HTS) of the AstraZeneca naloxone hydrochloride collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC=0.52

• br Materials and Methods br Results br Discussion Even

  2021-01-20

  

  Materials and Methods Results Discussion Even though T cell checkpoint inhibitors alone have achieved impressive clinical benefit in some cancers, their application as single agents has had limited efficacy (Hamid et al., 2013; Wolchok et al., 2013). The resistance to immunotherapy is in pa

• 2-Phenyl-2-(1-piperidinyl)propane Introduction Eicosanoid li

  2021-01-20

  

  Introduction Eicosanoid lipid prostaglandin D2 (PGD2) is the major prostaglandin produced by activated mast 2-Phenyl-2-(1-piperidinyl)propane (Lewis and Austen, 1981). The physiological function of PGD2 is mainly mediated by two G protein-coupled receptors (GPCRs), PGD2 receptor 1 and 2 (DP1 and DP

• Furthermore many intermediate plants did

  2021-01-20

  

  Furthermore, many intermediate plants did not show additive combinations of parental allozymes, which would be expected in F1 hybrids. The absence of some characteristic parental bands suggests that sexual reproduction has occurred among the hybrid plants. Genetic variations within and among the int

• The contradictory effects exerted by metals were reviewed by

  2021-01-20

  

  The contradictory effects exerted by metals were reviewed by Nunes (2011) that stated that the concentration and the species of metal can cause specific effects in ChE activity. Being environmentally exposed, the organism can accumulate metals in tissues, increasing their concentrations. Some author

• Hyper Assembly australia Mulan is a mitochondrial protein

  2021-01-19

  

  Mulan is a mitochondrial protein and is exclusively localized in the OMM with its RING domain facing the cytosol [14]. Based on this topology, Mulan can provide a link between molecular events in the mitochondria and cytoplasm. Mulan has been implicated in various processes including: mitochondrial

• CIC mediated chemoresistance is driven by several

  2021-01-19

  

  CIC-mediated chemoresistance is driven by several factors. In our quest to learn about these, we examined the crucial mediators identified earlier in the regulation of CSC survival and chemoresistance, such as BCL2, cleaved Caspase-3, COX-2, and macrophages. Interestingly, we observed a significantl

14880 records 714/992 page Previous Next First page 上5页 711712713714715 下5页 Last page