• CXC chemokines are primarily expressed in immune organs and

  2019-08-19

  

  CXC chemokines are primarily expressed in immune organs and the central nervous system: the mouse thymus and spleen (Heesen et al., 1996), chicken bursa (Liang et al., 2001), primate (Macaca mulatta) Darunavir Ethanolate (Federsppiel et al., 1993) and cattle locus coeruleus, cerebellum and pons (Rim

• Fluorescein-12-dUTP Regarding the effects of CRF on anxiety

  2019-08-19

  

  Regarding the effects of CRF on anxiety, Sahuque et al. (2006) have demonstrated that this neuropeptide also enhances anxiety when injected into the bed nucleus of the stria terminalis (BNST), a Fluorescein-12-dUTP structure that has also been related to defensive behavior (Casada and Dafny, 1991,

• br Materials and methods br Results Recently a quantitative

  2019-08-17

  

  Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis

• Perturbations in cell cycle are known to induce

  2019-08-17

  

  Perturbations in Mifepristone are known to induce apoptosis. Our results show that a fraction of the DT40YB-1b+/− cells, in addition to becoming tetraploids, undergo apoptotic cell death. Similar observations linking polyploidy and apoptosis have been made in the past [23], [30], [31], [32], [33], [

• br Methods br Results Main characteristics of study

  2019-08-17

  

  Methods Results Main characteristics of study population are presented in Table 1. AD cases had higher co-morbidity score and lower socioeconomic position than controls. Women with AD had undergone any surgery (unilateral/bilateral oophorectomy, hysterectomy, hysterectomy with bilateral oophor

• Studies have shown that endothelial cells damaged by SAH

  2019-08-17

  

  Studies have shown that endothelial cells damaged by SAH can release a large amount of ET-1, thus its plasma level is elevated and is positively correlated with the symptoms of SAH (Lei et al., 2015, Masaoka et al., 1989). Our data obtained from SAH-along rabbits were consistent with these findings.

• Our results indicate an OT

  2019-08-17

  

  Our results indicate an OT-specific activation of PKR that inactivates eIF2a and may, by this means, reduce protein translation by utilizing only select sensors and mediators of the UPR (i.e., avoiding significant PERK activation). Interferon is a PKR activator [32] that temporarily subdues cellular

• Introduction Protein ubiquitination is a posttranslational m

  2019-08-17

  

  Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012). It involves the covalent attachment of ubiquitin (Ub) via its C-terminal glycine carboxylate to a primary amin

• Cdc which is involved in filopodium formation and Rac

  2019-08-17

  

  Cdc42, which is involved in filopodium formation, and Rac1, which is involved in lamellipodium formation, engage in cross-talk with one another [25,26,30,31]. In general, filopodium formation precedes lamellipodium formation, and filopodium formation (Cdc42 activity) suppresses lamellipodium formati

• RDH belongs to C family of

  2019-08-17

  

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,

• Overexpression of EP and DDR has been sporadically reported

  2019-08-17

  

  Overexpression of EP300 and DDR1 has been sporadically reported in the pathogenesis of pulmonary fibrosis and other fibrotic diseases. Zeng et al. reported that EP300 was increased in TGF-β1 treated lung fibroblasts and mediated decreases of SIRT1 expression. Bhattacharyya et al. found that both EP3

• The large body of structural knowledge that is

  2019-08-17

  

  The large body of structural knowledge that is currently available for CRM1 has contributed to atomic level and mechanistic understanding of many steps in the CRM1 nuclear export cycle. However, structural analysis could still inform on several outstanding questions and guide future discoveries pert

• Physiological changes induced by CRF are mediated

  2019-08-16

  

  Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,

• Under conditions of energy scarcity or

  2019-08-16

  

  Under conditions of energy scarcity or nutritional restriction, AMPK, a critical energy sensor, is activated in response to the increased ratio of AMP to ATP. Various kinases may phosphorylate AMPK, leading to its activation. For example, AMPK phosphorylation by liver kinase B 1 (LKB1) at Thr172 res

• While apparent that His Artemis

  2019-08-16

  

  While apparent that [His]6-Artemis fractionated over a HAP column is devoid of 5′–3′ exonuclease activity but still retains DNA-PK dependent hairpin-opening activity, we sought to further assess DNA-PK dependent Artemis overhang cleavage activity to ensure all the in vivo, intrinsic enzymatic activi

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