• The assessment process is even more difficult

  2019-10-11

  

  The assessment process is even more difficult when Commercial-Off-The-Shelf (COTS) components – whose internals are partially or totally unknown – come into play. COTS are being increasingly used by the industry to reduce costs and to shorten development (and possibly deployment) time. However, sinc

• br Roles of TLS polymerases outside DNA damage tolerance br

  2019-10-10

  

  Roles of TLS polymerases outside DNA damage tolerance Preparing the ground for more DNA damage: adaptive responses through gene induction Conclusions and perspectives Although known for many decades, the relevance of TLS in genome stability is normally considered secondary to mechanisms tha

• The discoidin domain receptors DDR

  2019-10-10

  

  The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases (RTKs) that are stimulated by collagen in the extracellular matrix (ECM). Unlike most other RTKs, they form ligand-independent stable dimers that are non-covalently linked. This ECM activation induces receptor phosphorylati

• In recent years there has been a dramatic increase

  2019-10-10

  

  In recent years there has been a dramatic increase in identification and optimization of potent CRTh2 antagonists which may not only inhibit the recruitment and activation of Th2 cells but also accelerate apoptosis and clearance of these cells from inflamed tissue, thereby promoting the resolution o

• In addition to its HEAT repeats CRM also

  2019-10-10

  

  In addition to its HEAT repeats, CRM1 also possesses a C-terminal extension (C-extension, residues 1032–1071), composed of a helix (C-helix) followed by a short stretch of residues (C-tail). In the absence of Ran, the C-extension adopts a conspicuous conformation that bridges across the ring-shaped

• WRTs AI AI and AI showed

  2019-10-10

  

  WRTs AI-82/1, AI-9-1 and AI-60 showed the same ST as was published by Dingle et al. in RTS 103, 013 and 097 (Dingle et al., 2011). WRTs 015 and 002 were assigned as WRTs 015-like and 002-like due to slight changes in their CE-ribotyping profiles; however, the ST of WRT 002-like (ST8) was identical t

• br Materials and methods br Results br

  2019-10-10

  

  Materials and methods Results Discussion Prolyl 4-hydroxylases are oxygenases with key roles in a variety of biological processes including oxygen sensing, siRNA regulation and collagen folding (Gorres and Raines, 2010). Hydroxyproline is particularly abundant in collagenous proteins which

• br Conclusions br Statement of authorship

  2019-10-10

  

  Conclusions Statement of authorship Nonaneurysmal subarachnoid hemorrhage (NA-SAH) differs from aneurysmal subarachnoid hemorrhage (SAH) in both clinical course and outcome. In spite of many reports and case series since the first description in 1985, the etiology of NA-SAH remains uncertain

• Several questions remain to be addressed

  2019-10-10

  

  Several questions remain to be addressed. The hormones and metabolites that modulate expression of EERγ in the steps leading to maturation need to be identified to learn more about physiological and pathophysiological regulation of EERγ in β cells. Considering that ERRγ repressed cell cycle genes in

• EphB promotes tumor growth by

  2019-10-10

  

  EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of Tacedinaline and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood vesse

• The activity of chromenones bearing heteroaryl

  2019-10-09

  

  The activity of chromenones bearing heteroaryl groups at the 8-position is summarised in . Replacement of the 8-phenyl substituent of by a thiophen-2-yl group ( and ) did not improve DNA-PK inhibitory activity, although the 4-phenylthiophen-2-yl derivative (), together with the bithiophene analogue

• In the present study we combined activity

  2019-10-09

  

  In the present study, we combined activity-based protein profiling, biochemical and genetic approaches to identify the PLCPs involved in the sphingolipid pathway leading to plant PCD. By using Arabidopsis Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) and leaves, we demonstrate that this sub-class

• Lipolysis and fatty acid oxidation are

  2019-10-09

  

  Lipolysis and fatty q 10 mass oxidation are two important mechanisms involved in fat reduction. Over stimulation of lipolysis increases the level of FFAs in the serum and causes metabolic perturbation (Koutsari and Jensen, 2006). A large inflow of FFAs to the mitochondria may lead to mitochondrial

• br Materials and methods br

  2019-10-09

  

  Materials and methods Results Discussion In this study, we uncovered a female-specific haplotype-MDD vulnerability association, by which a two-marker haplotype TG of rs4633-rs4680 may link to enhanced MDD risk in females. Female haplotype TG carriers were estimated to have a 9.17-fold incre

• The present study was the first

  2019-10-09

  

  The present study was the first to examine how COMT genotype and estradiol are associated with Epiberberine functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would remain and perhaps bec

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